The Cardioactive Glycosides
نویسندگان
چکیده
منابع مشابه
The cardioactive metabolites of digitalis glycosides.
There is little known about the nature of the metabolic products derived from cardiac glycosides in the animal body. Reports of the formation of digitoxigenin from the glycoside digitoxin in vivo have appeared in the literature (l-3), but reliable chemical methods of identification applicable to the very small quantities of material involved were not available to these workers. Fischer, Sjoerds...
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Most patients who have taken a large dose of a beta-blocker will demonstrate bradycardia and hypotension. With very large doses there will be coma, convulsions and profound hypotension. A variety of cardiac dysrhythmias and ECG abnormalities are described. The more serious of these can result in cardiorespiratory arrest.2,3 These include: heart block intraventricular conduction defects ST...
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The Ebers Papyrus provides evidence that the Egyptians used plants containing cardioactive steroids (CASs) at least 3000 years ago. However, it was not until 1785, when William Withering wrote the first systemic account about the effects of the foxglove plant, that the use of CASs was more widely accepted into the Western apothecary. Foxglove, the most common source of plant CAS, was initially ...
متن کاملThe Cardiac Glycosides
author offers no evidence to support his own contentions other than "laboratory studies show," "phylobiological investigations show," "my researches and those of my associates show." A really specific account of the therapeutic method to be used, or how the physiological method is to be applied, is found nowhere in the book, nor are any concrete case histories supplied. A much-needed glossary, ...
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F90927 is a newly developed cardioactive drug with a steroid-like structure. It acts directly and agonistically on the cardiac L-type Ca2+ channel by shifting its voltage-dependent activation toward more negative potentials. This leads to an increased influx of Ca2+ and, therefore, to a stronger contraction; however, no arrhythmias occur. Calcium current stimulation can already be observed at n...
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ژورنال
عنوان ژورنال: Journal of Pharmacy and Pharmacology
سال: 1949
ISSN: 2042-7158,0022-3573
DOI: 10.1111/j.2042-7158.1949.tb12507.x